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29a- b. CHARACTERS A white or almost white, crystalline powder, slightly hygroscopic. [42] Nickerson, 102 mechanical 34 primary care 10910 psychosocial factors 138 surgery 111 low intensity ultrasound 128 magnetic resonance imaging, bone 845 managed care 10 management of chronic disease changing approach 100 competency 15 current issues 58 problems 78 future provision 1113 evidence base 13 goals 4, 113 multidisciplinary nature 6, 11, 17 non-pharmacological 10810 self-management see self- management see also healthcare provision; specific conditions metalloproteinases (MMPs), therapeutic targets 445 methotrexate 26 mindbody problem 114 mitogen activated protein kinase (MAPK) pathway 43 mortality 20, 21 multidisciplinary teams 6, 11, 17 fragility fracture treatment 133 pain management 109, 117 patients 15 rheumatology 523, 53 musculoskeletal conditions 118 chronic pain see chronic musculoskeletal pain definition 1 epidemiology 22, 119, 119 evidence base 13, 120 global burden 12, 1939 healthcare needs 3 ideal care model 1316 audit 16 clinical information system 16 community role 1314 decision support 16 delivery system 1516 health system 1415 obstacles 1718 self-management 15 management see management of chronic disease morbidity 20 mortality 20, 21 need for greater resources 1617 prevention 12 traffic accidents 121 see also specific conditions musculoskeletal pain acute 101 chronic see chronic musculoskeletal pain musculoskeletal trauma see trauma National Collegiate Athletic Association (NCAA), sports injury data 136 National Institutes of Health (NIH) 79 natural disasters 139 neural plasticity and pain 99, 103, 111, 114 non-pharmacological interventions pain management 10810, 115 rheumatoid arthritis 55 non-steroidal anti-inflammatory drugs (NSAIDs) 55 osteoarthritis treatment 67 rheumatoid arthritis treatment 55 see also individual drugs nuclear factor B (NF-B), therapeutic targets 423 obesity 116 osteoarthritis 67 operative analgesia 111 opioids 1067 orthopaedics 5 acute 130 fragility fractures 133 trauma care 146 PATHOGENESIS OF BRAIN TUMORS AND ROLE OF STEM CELLS 911 Fig.

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