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Edited by Anthony Meager Copyright © 1999 John Wiley Sons Ltd Print ISBN 0-471-976709-2 Hotforex review 2017 ISBN 0-470-84238-5 Index Adeno-associated viral (AAV) vectors, 11421, 128, 1867, 202, 214, 2312, 304, 323 AAVCFTR, 116, 119, 120, 121, 214 ADA-SCID, 1867 anti-sense gene delivery, 299300 advantages, 1178 applications, 11720 cystic fibrosis, 214 disadvantages, 1178 environmental safety, 121 haemoglobinopathies, 2312, 234, 237 haemophilia B, 202 helper virus (adenovirus), 114 host cell factors in vector transduction, 1167 in vitro applications, 1189 in vivo applications, 120 packaging, 115, 365 persistence of vector DNA in target cells, 116 safety issues, 1201 structure, 114, 115, 231 subject safety, 1201 vector shedding, 121 Adeno-associated virus (AAV), 10914 biology, 10914 cap gene, 111, 114, 304 capsid proteins, 112 hotforex review 2017 19 integration site, 112, 113 electron micrograph of AAV2, 110 inverted terminal repeats (ITR), 1101, 114, 115, 117 life cycle, 1123 rep gene, 110, 1112, 114, 117, 120, 144, 304 rep proteins, 1112, 114, 115, 116, 231 serotypes, 10910 site-specificity of AAV integration, 1134 structure of genome, 1102 Adenoviral vectors, 87100, 128, 323 advantages, 87 adenoviral DNA-containing plasmids, 93 Av1CFTR vector, 96, 2113 circumvention of host immune response, 979 conditional lethal phenotype, 92 design of replication-defective human adenoviral vectors, 903 disadvantages, 87 E1 specific PCR analysis, 95 E1 replacement vectors, 901 1st generation (Av1) vectors, 902, 94, 95, 96, 97, 100, hotforex review 2017, 259 2nd generation (Av2) vectors, 98, 100, 258 3rd generation (Av3) vectors, 98, 100 gutless vectors, 98, 100 haemophilia A, 200 haemophilia B, 201 host hotforex review 2017 response, 87, 96, 2134, 218, 258, 283 packaging cell lines, 945 particle to infectious unit ratio, 95 propagation and purification, 945 replication-competent adenovirus (RCA), 94, 95, 99, 100 titres, 95 in vivogene transfer, 957 Adenovirus, 8890 adenovirus genes, 8890 adenovirus inverted terminal repeats (ITR), 88, 89, 90, 91 early region genes, E14, 8890, 93, 94, 98 structure and genomic organisation, 8890 subgroup C adenoviruses, 90 Hotforex review 2017 variant ONYX replication competent vector, 349 Alpha-satellite DNA, 168, 171, 172 Creating an inner class directly using the.
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